ECFS

Acetylcysteine

A

MEDICATION TYPE

Mucolytic

INDICATIONS

Oral
Treatment of distal intestinal obstruction syndrome (DIOS) previously called meconium ileus equivalent.

Nebulised: Mucolytic
Given for the duration of the intravenous aminoglycoside treatment to prevention aminoglycoside induced ototoxicity.

NOTES

Inhaled use in CF largely superseded by dornase alfa and hypertonic saline.

Source: BNF 87· Last reviewed 6/17/2026· Reviewed by Professor Daniel Peckham· v4

MEDICAL WARNING

Acetylcysteine should only be administered under the supervision of a healthcare professional. Always verify against current BNF and your local CF protocol before prescribing.