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Amikacin
MEDICATION TYPE
Antibiotic
INDICATIONS
Treatment of Pseudomonas aeruginosa, Burkholderia cepacia complex and Mycobacterium abscessus infections.
DRUG INTERACTIONS
Alendronate (Bisphosphonates)
Increased risk of hypocalcaemia.
Amphotericin
Increase risk of nephrotoxicity.
Capreomycin
Increased nephrotoxicity and ototoxicity.
Colistin
Increased risk of ototoxicity and nephrotoxicity.
Cyclosporin
Increased risk of nephrotoxicity and increased levels of both drugs. Reduce aminoglycoside dose is essential and monitor cyclosporin levels carefully.
Frusemide (Loop diuretics)
Increase risk of ototoxicity.
Indomethacin
Increased plasma concentration of amikacin.
Neostigmine/pyridostigmine
Antagonism of effect.
Non-depolarising muscle relaxants
Enhances effect e.g. atracurium, vecuronium, pancuronium.
Teicoplanin
Increased nephrotoxicity and ototoxicity.
Vancomycin
Increased risk of nephrotoxicity and ototoxicity.
NOTES
(Amikacin is not licensed for the treatment of NTM in the UK)
MEDICAL WARNING
Amikacin should only be administered under the supervision of a healthcare professional. Always verify against current BNF and your local CF protocol before prescribing.