%20--%3e%3cdefs%3e%3cstyle%3e%20.st0%20{%20fill:%20%23fff;%20}%20%3c/style%3e%3c/defs%3e%3cpath%20class='st0'%20d='M26.036.129C10.532.129,0,11.725,0,26.029s10.883,25.899,26.036,25.899c11.829,0,20.428-6.6,23.938-15.983l-13.165-.147c-2.436,3.026-6.115,4.93-10.677,4.93-6.945,0-12.242-4.724-13.741-11.122l39.12-.039c.138-1.157.209-2.338.209-3.538C51.72,11.725,41.1.129,26.036.129ZM13.144,19.67c2.092-5.128,6.816-8.69,12.987-8.69,6.003,0,10.709,3.571,12.799,8.708l-25.786-.018ZM117.213,18.171c0-1.845,1.504-3.341,3.359-3.341l17.801.005V.129h-19.144c-10.017,0-18.137,8.078-18.137,18.042v18.381l-22.335-.006c-6.028,0-10.915-4.862-10.915-10.858s4.887-10.858,10.915-10.858h20.992V.129h-20.992c-14.376,0-26.029,11.593-26.029,25.893s11.654,25.893,26.029,25.893h22.335v38.088h16.121v-38.088h35.602v-15.363h-35.602v-18.381ZM148.784,40.478v7.434h-35.266v38.417h-8.397v-38.417s-14.216-.005-26.365-.005-21.999-9.798-21.999-21.884,9.849-21.884,21.999-21.884h16.961v6.682h-16.987c-8.24,0-14.92,6.645-14.92,14.842s6.68,14.842,14.92,14.842l26.392-.026v-22.307c0-7.75,6.316-14.032,14.106-14.032h15.45v6.688l-14.106-.005c-4.081,0-7.389,3.291-7.389,7.35v22.307h35.602ZM179.685,20.691c-5.483-1.881-10.305-3.198-10.305-6.019v-.188c0-1.975,1.796-3.48,5.294-3.48,3.687,0,8.698,1.787,13.709,4.703l5.483-9.875C188.383,2.163,181.387,0,174.958,0,164.747,0,156.427,5.737,156.427,15.988v.188c0,9.781,8.036,13.073,15.127,15.142,5.578,1.693,10.494,2.728,10.494,5.831v.188c0,2.257-1.891,3.762-6.051,3.762-4.727,0-10.494-2.069-15.978-6.019l-6.145,9.405c6.713,5.267,14.654,7.618,21.745,7.618,10.967,0,19.381-5.079,19.381-16.27v-.188c0-9.217-8.225-12.602-15.316-14.954Z'/%3e%3c/svg%3e)
Amphotericin
A
MEDICATION TYPE
Antifungal
INDICATIONS
Systemic fungal infections. Oral candidiasis.
DRUG INTERACTIONS
Aminoglycosides
Increased risk of nephrotoxicity.
Corticosteroids
Increases risk of hypokalaemia.
Digoxin
Increased toxicity with hypokalaemia.
Tacrolimus, Cyclosporin
Increases risk of nephrotoxicity.
NOTES
Liposomal formulation (AmBisome®) preferred for reduced nephrotoxicity.
MEDICAL WARNING
Amphotericin should only be administered under the supervision of a healthcare professional. Always verify against current BNF and your local CF protocol before prescribing.