Ibuprofen

MEDICATION TYPE

NSAID

INDICATIONS

Treatment of mild to moderate pain, particularly related to inflammation, gout.

DRUG INTERACTIONS

ACE inhibitors
Reduced anti-hypertensive effect, increased risk of renal impairment.

Anticoagulants
Enhanced anticoagulant effect.

Anti-hypertensives
Reduced anti-hypertensive effect.

Ciprofloxacin (Quinolone antibiotics)
Enhanced risk of convulsions.

Cyclosporin
Increased risk of nephrotoxicity.

Digoxin
NSAIDs may exacerbate cardiac failure, reduce GFR and increase plasma digoxin levels.

Diuretics
NSAIDs reduce the diuretic effect. Diuretics can increase the risk of nephrotoxicity of NSAIDs.

Lithium
Decreases elimination of lithium.

**Methotrexatev
Decreased elimination of methotrexate.

Prednisolone
Increased risk of gastric bleeding.

SSRIs and venlafaxine
Increased risk of bleeding.

Tacrolimus
Increased risk of nephrotoxicity.

NOTES

High-dose CF use requires TDM; concomitant aminoglycoside increases nephrotoxicity.