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Methylprednisolone
MEDICATION TYPE
Steroid
INDICATIONS
Reduction of respiratory inflammatory once infection is under control.
DRUG INTERACTIONS
Amphotericin
Increased risk of hypokalaemia.
**Antidiabetics
Antagonism of hypoglycaemic effect.
Cyclosporin
Cyclosporin levels increased.
Digoxin
Potentiates hypokalaemia and may therefore result in toxicity.
Diuretics
Antagonism of diuretic effect.
Itraconazole
Possibly inhibits metabolism of methlyprednisolone.
Rifampicin
Accelerates metabolism of corticosteroids.
Theophylline
Increased risk of hypokalaemia.
Vaccines
Immune response impaired: avoid live vaccines.
NOTES
Pulse doses often used for transplant rejection.
MEDICAL WARNING
Methylprednisolone should only be administered under the supervision of a healthcare professional. Always verify against current BNF and your local CF protocol before prescribing.