Minocycline

MEDICATION TYPE

Antibiotic

INDICATIONS

Respiratory infection due to Burkholderia cepacia and Stenotrophomonas maltophilia. Treatment of Mycobacterium abscessus infection.

DRUG INTERACTIONS

Aluminium
Reduced absorption of minocycline (take minocycline at least 2–3 hours before or after aluminium-containing preparations).

Anticoagulants
Prolonged prothrombin time in patients taking warfarin (monitor INR and reduce warfarin dose).

Calcium
Reduced absorption of minocycline (take minocycline at least 2–3 hours before or after calcium-containing preparations).

Contraceptives
Reduced effect of oral contraceptives.

Iron
Reduced absorption of minocycline (take minocycline at least 2–3 hours before or iron-containing preparations).

Lithium
Case reports of increased serum lithium levels (monitor levels).

Magnesium
Reduced absorption of minocycline (take minocycline at least 2–3 hours before or after magnesium-containing preparations).

Retinoids
(eg, acitretin, isotretinoin): risk of pseudotumour cerebri (benign intracranial hypertension).

Zinc
Reduced absorption of minocycline (take minocycline at least 2–3 hours before or after zinc-containing preparations).

NOTES

Avoid prolonged courses; avoid <12 yrs.