Moxifloxacin

MEDICATION TYPE

Antibiotic

INDICATIONS

Second line treatment for community acquired pneumonia, used as part of regime to treat atypical mycobacterium abscessus.

DRUG INTERACTIONS

Amiodarone
Increased risk of ventricular arrhythmias – avoid concomitant use.

Chlorquine and Hydroxychloroquine
Increased risk of ventricular arrhythmias – avoid concomitant use.

Ciclosporin
Increased risk of nephrotoxicity.

Disopyramide
Increased risk of ventricular arrhythmias – avoid concomitant use.

Haloperidol
Increased risk of ventricular arrhythmias – avoid concomitant use.

Intravenous erythromycin
Increased risk of ventricular arrhythmias – avoid concomitant use.

Iron
Reduces absorption of Moxifloxacin.

Mizolastine
Increased risk of ventricular arrhythmias – avoid concomitant use.

NSAID
Increased risk of convulsions.

Phenothiazides
Increased risk of ventricular arrhythmias – avoid concomitant use.

Pimozide
Increased risk of ventricular arrhythmias – avoid concomitant use.

Procainamide
Increased risk of ventricular arrhythmias – avoid concomitant use.

Quinidine
Increased risk of ventricular arrhythmias – avoid concomitant use.

Sertindole
Increased risk of ventricular arrhythmias – avoid concomitant use.

Sotolol
Increased risk of ventricular arrhythmias – avoid concomitant use.

Theophylline
Increases plasma concentration of theophylline, increased risk of convulsions.

Tricyclic antidepressants
Increased risk of ventricular arrhythmias – avoid concomitant use.

Zinc
Reduces absorption of Moxifloxacin.

NOTES

MHRA warning on fluoroquinolones — disabling persistent side effects.