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Piperacillin and tazobactam
P
MEDICATION TYPE
Antibiotic
INDICATIONS
Treatment of Pseudomonas aeruginosa and Burkholderia respiratory infections. Activity against H influenzae.
DRUG INTERACTIONS
Methotrexate
Increased risk of toxicity.
Muscle relaxants
Enhanced by Piperacillin.
Probenecid
Reduced Piperacillin excretion.
NOTES
Extended infusion sometimes used to optimise PK in CF.
MEDICAL WARNING
Piperacillin and tazobactam should only be administered under the supervision of a healthcare professional. Always verify against current BNF and your local CF protocol before prescribing.