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Trimethoprim
MEDICATION TYPE
Antibiotic
INDICATIONS
Treatment of urinary and respiratory infections caused by sensitive organisms.
DRUG INTERACTIONS
Cyclosporin
Increased risk of nephrotoxicity. ? Reduced cyclosporin concentration.
Dapsone
Plasma level of both drugs increased.
Methotrexate
Antifolate effect increased, increased risk of haematological toxicity.
Phenytoin
Level of phenytoin increased.
Procainamide
Increased concentrations of procainamide.
Repaglinide
Enhances hypoglycaemic effect avoid concomitant use.
Warfarin
Anticoagulation effect enhanced.
NOTES
Monitor U&Es with long-term use.
MEDICAL WARNING
Trimethoprim should only be administered under the supervision of a healthcare professional. Always verify against current BNF and your local CF protocol before prescribing.